Callie was first introduced as the orthopedic resident who fixed George's dislocated shoulder in the ER. Then she told him that Callie is who he raised her to be. [20], A day later during lunch time, Callie told Addison that George kissed her. They agreed that last night was fun, and they both commented that they were not a group person because they generally don't like people. George said that he was only scared of her because of the staring. At the hospital, George came to Callie to ask her about the room service bill. She talks to a Navaho man who says she needs to burn anything that belongs to him. Subsequently, Callie decided to have a baby with George, a request to which he agrees. Arizona Robbins (ex-wife)George O'Malley † (ex-husband) Addison manages to save the baby and the woman dies.Upset with losing his patient, Derek punches Mark when Mark says he's in a relationship with Lexie. Callie told her that she was very good at her job. He wants Cristina's support, but she says she doesn't want him to die and can't support him. [47], Trying to forget Addison's comments, Callie constantly wanted to have sex with Mark in the on-call rooms. Derek won't come to work after making a mistake that killed a woman. George left to take care of a patient, but he later told her they could do it if that's what she really wanted. George then agreed and walked away. At work, by saying she might be pregnant, Callie tried to cheer up George, who was a bit depressed because he was still an intern while the others passed their intern exams. Because of that, Meredith opened up to Callie about things that she doesn't tell everyone. During that time, she and Arizona hit a rough patch, when she found out Arizona did not want kids. Addison and Callie worked together on a case that day, starting off their friendship. So she paged Meredith to a room to show her scans of a human with bone cancer, and explained some more to her about the disease. [4], Shortly after, Callie got to know George's friends. Addison wasn't paying attention, and when Callie made a comment on that, Addison told her that she aborted Mark's baby 8 months ago. It tells us what we see, what we hear. Izzie waits until everyone leaves the room, and then throws up. [23], At the hospital, Callie told Bailey that it was weird being married to someone she was the boss of. Derek tries to save mother and baby by removing parts of the mother's brain. Her tests reveal that she is anemic.Derek is ready to propose to Meredith. At the end of the day, George came to Callie's hotel room to have sex again, but Callie told him she couldn't have sex anymore. Callie also watched George feeding Izzie part of his lunch while laughing together. In the end, Richard offered her the post of an attending surgeon. Owen is very distant to Cristina and she confronts him. In the hospital, Izzie and Meredith assisted her on an ortho case. She finally figures out that she is dying and he's there to take her away. Bailey suggests that he give up his wedding day for Alex and Izzie. Callie accepted George's proposal, and the couple got married in Las Vegas, leading Alex and Dr. Sydney Heron to dub her “Callie O’Malley”. Their patient was a pregnant woman whose baby died in the womb, which really saddened Addison. As her friends' hateful feelings towards Penny faded over time, Callie and Penny made up. He tells Cristina about the field and says she would be a good trauma surgeon. He told her that she shouldn't talk to his family as she broke up with him. She checks his hand and starts sobbing silently, confirming it is him. She went to the ER, where she stood outside with Addison, the Chief and Yang, waiting for the first patient to arrive. George also discovered Callie lived in the hospital basement. [10], When Addison hung Meredith's panties, which she found in Derek's pocket, up on the bulletin board, Callie came to the rescue and claimed them, apologizing for leaving her underwear lying around again. While they were talking, George came in, saying that he was jealous and didn't want other guys to touch her panties. Cristina told her she was literally left in the church, wearing a wedding dress. Meredith honestly thanked Callie for that. At first, Addison asked her why they got married so fast, but then just congratulated and hugged her. Back at the hospital, Izzie tells Denny that it was a beautiful wedding. Mark began to tease the two about how close they were, talking about them kissing and asking Callie if she ever thought about grabbing Erica's hair in surgery and kissing her. He kissed her and the two proceeded to have sex. Callie explained that she didn't tell him about it because the money had affected every relationship she'd had.

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